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WHY APPLY MECHANICAL LOAD TO CULTURED CELLS?
Cells are subjected to compression, tension, and shear in the body and undergo specific biochemical changes to respond and adapt to deformation. Stressing cells in culture simulates the in vivo environment causing dramatic morphologic and biochemical responses. There are both short and long term changes that occur when cells are loaded in culture, such as alterations in signaling, the rate and amount of protein synthesis, secretion, or degradation, the rate of cell division, changes in energy metabolism, and other changes in biochemistry and bioenergetics.
For these reasons, Flexcell® introduced tension, compression, and fluid shear systems for cell culturing. These systems have broad applications in the biomedical research field since strain, compression, or fluid flow have been found to induce biochemical changes in cells derived from a variety of tissues including cardiac, skeletal and smooth muscle, lung, vascular endothelium, skin, tendon, ligament, cartilage, and bone. Please see our selected publications for a list of articles about the effects of mechanical load applied with Flexcell equipment on various cell types.
OUR FACILITYFlexcell® is a privately held, for-profit company incorporated in 1987. Flexcell® currently maintains operations in Hillsborough, North Carolina. The facility occupies approximately 10,000 sq. ft. and is home to our research & development, product engineering, manufacturing, marketing, sales, and warehousing departments.
To support these activities, Flexcell® directly employs twelve staff members. Additionally, Flexcell® uses contract labor to supplement specific short term needs.
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