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Anti-Rat CD11b/c APC (Clone OX-42) (mouse IgG2a)

Cedarlane
Product Code:
CL042APC
Supplier Name:
Cedarlane
Size:
100ug
Data Sheet:
View Data Sheet
Categories:
OX-42

Additional Product Details

Applications:
F
Clone:
OX-42
Format:
APC
Isotype:
Mouse IgG2a
Specificity:
CD11b/c (pan macrophage)
Host:
Mouse
Conjugate:
Allophycocyanin
Species Reactivity:
Rat
$419.00 CDN


  • Description

    Cedarlane’s anti-rat CD11b/c monoclonal antibody recognizes most macrophages including resident peritoneal macrophages, kupffer cells, but only approximately 35% of alveolar macrophages (2). It also labels dendritic cells extensively, granulocytes and cells with morphology of microglia in the brain. It precipitates three polypeptides of M.W. 160, 103 and 95kDa. OX-42 inhibits complement mediated rosettes and is probably the rat equivalent of the human receptor for iC3b called CR3. Cedarlane’s anti-rat CD11b/c mAb should prove useful in the recognition of macrophages and microglia.
    This clone is reported to work with frozen and paraffin sections (3); in vivo and in vitro functional tests (4, 5, 6); and cryostat sections (5).
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    Flow Cytometry Analysis
    Wistar rat peritoneal macrophages were stained with anti-CD11b/c (clone: OX-42) (filled histogram) or mouse IgG2a isotype control (open histogram).

  • References

    1)  Aihara, N. et al. (1995) J. Neurotrauma. 12:53-63.

    2)  Robinson, A.P. et al. (1986) Immunology. 57:239-247.

    3)  Whiteland J.L. et al. (1995) J. Histochem and Cytochem. 43:313-320.

    4)  Issekutz, A. C. and T.B. Issekutz, (1992) Immunology. 76:655-661.

    5)  Yamazaki, T. et al. (1993) Am. J. of Pathology. 143:410-418.

    6)  Tamatani, T. et al. (1991) Eur. J. Immunol. 21:627-633.

    7)  Joan Y. et al. (2009) Am J Physiol Regul Integr Comp Physiol. 297:R1532-R1545.

    8)  Zheng Gen Piao et al. (2005) Pain. 121:219-231.

    9)  Abbadie C. et al. (2003) PNAS. 100:7947-7952.
    10) Lee. et al. (2010) Molecular Pain. 6:79.
    11) Summy-Long, J.Y. et al. (2008) Journal of Neuroendocrinology. 20:1224-1232.