Adult Mouse Astrocyte Cell Line mHypoA-Ast1/2 (male; Hypothalamus derived)

This product line is based on proprietary platform technology which has enabled the creation of a series of immortalized glial cell lines isolated from mouse brain. These neurons were immortalized via retroviral transfer of SV40 T-Ag into glial cell primary cultures isolated from various regions (hypothalamus, cortex and brainstem) of adult CD-1 mice brains. These cell lines have been found to express an ever-expanding array of glial cell specific markers. As such, these cell lines enable accurate in-vitro assays for use in the discovery, development and validation of new therapeutics targeted to central-nervous system diseases and disorders, including obesity and neurodegenerative diseases.

Further details regarding these cell lines can be found in the following paper:

• Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem

The datasheet for this product can be downloaded here.