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Complement Component C3 Antibodies

Complement Component C3 Antibodies


  • Complement Component C3

    Complement component C3 (C3) is an immune system protein that plays a central role in the classical and alternative complement activation pathways. In the classical complement pathway activation is seen to be antibody dependent. Downstream of this activation, C3 is cleaved to C3a and C3b by a C3 convertase (C4b2a). In contrast to the classical pathway, C3 is critical for initiation of the alternative complement pathway. C3b that arises from spontaneous hydrolysis of C3 binds microbial surfaces and remains in an active form. Bound C3b binds Factor B and makes it susceptible to cleavage by Factor D. The resulting C3 convertase (C3bBb complex) further enhances processing of C3 to C3a and C3b. C3a is released from the surface and functions as a peptide mediator of inflammation (anaphylatoxin). C3b becomes an integral part of the C5 convertases in both the classical and alternative pathways. These lead to the processing of C5 to C5a and C5b and ultimately to the generation of the membrane attack complex (MAC).

    Antibodies

    Specificity Clone Isotype Species Reactivity Application
    C3 RmC11H9 Rat IgG2a Mouse IF, C, WB, E
    C3a/C3a(desArg)/C3 K13/16 Mouse IgG1 K Human FN, IP, E, WB
    C3/C3b/iC3b 6C9 Mouse IgG1 Human/Mouse F, E
    C3/C3b/iC3b 10C7 Mouse IgG1 Human/Mouse F, E
    C3/C3b/iC3b 7C12 Mouse IgG1 Human WB, F, E
    C3/C3b/iC3b/C3d 1H8 Mouse IgG2a Human WB, F, E

    ELISA

    Human C3a/C3a desArg, 96 wells CL76160K Human E
Found 54 Products
Showing Page 1 of 6
       
Product Name: Anti-Mouse Complement Component C3, Purified (Clone RmC11H9) (rat IgG2a)
Code:
CL7503AP
Supplier:
Cedarlane
Size:
250ug
Unit Price:
$379.00 CDN
Product Name: Anti-Mouse Complement Component C3, Purified (Clone RmC11H9) (rat IgG2a)
Code:
CL7503AP-2
Supplier:
Cedarlane
Size:
500ug
Unit Price:
$555.00 CDN
Product Name: Anti-Mouse Complement Component C3, APC (Clone RmC11H9) (rat IgG2a)
Code:
CL7503APC
Supplier:
Cedarlane
Size:
100 ug
Unit Price:
$420.00 CDN
Product Name: Anti-Mouse Complement Component C3, Biotin (Clone RmC11H9) (rat IgG2a)
Code:
CL7503B
Supplier:
Cedarlane
Size:
100ug
Unit Price:
$219.00 CDN
Product Name: Anti-Mouse Complement Component C3, FITC (Clone RmC11H9) (rat IgG2a)
Code:
CL7503F
Supplier:
Cedarlane
Size:
100ug
Unit Price:
$247.00 CDN
Product Name: Anti-Mouse Complement Component C3, 10 nm Gold Conjugate, OD3 (Clone RmC11H9) (rat IgG2a)
Code:
CL7503G
Supplier:
Cedarlane
Size:
0.5 mL
Unit Price:
$195.00 CDN
Product Name: Anti-Mouse Complement Component C3, 10 nm Gold Conjugate, OD3 (Clone RmC11H9) (rat IgG2a)
Code:
CL7503G-2
Supplier:
Cedarlane
Size:
1.0 mL
Unit Price:
$349.00 CDN
Product Name: Anti-Mouse Complement Component C3, No Azide (Clone RmC11H9) (rat IgG2a)
Code:
CL7503NA
Supplier:
Cedarlane
Size:
1mg
Unit Price:
$988.00 CDN
Product Name: Anti-Mouse Complement Component C3, PE (Clone RmC11H9) (rat IgG2a)
Code:
CL7503PE
Supplier:
Cedarlane
Size:
50ug
Unit Price:
$233.00 CDN
Product Name: Anti-Mouse Complement Component C3, TRITC, (Clone RmC11H9) (rat IgG2a)
Code:
CL7503TRC
Supplier:
Cedarlane
Size:
100ug
Unit Price:
$274.00 CDN
Found 54 Products
Showing Page 1 of 6

Custom Antibody Services

CEDARLANE® manufactures complement, Lympholyte® cell separation media, cell purification immunocolumns, neuronal cell lines and a wide range of antibodies. CEDARLANE® continues to offer our Custom Antibody Services and increased demand has lead to the continued expansion of our facility. We understand the varied nature of custom work and encourage you to call our qualified staff to discuss the details of your project. Please inquire about other services not listed. Be assured that we at CEDARLANE® are dedicated to ensuring the confidentiality of all projects we discuss.