25% OFF RNA METHYLATION KITS FROM EPIGENTEK
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Feb 13 2017
Apr 28 2017
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RNA Methylation Analysis Made Easy! Save 25% on Top Kits Today!
RNA methylation occurs in different RNA species including tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA-methyltransferases. As a post-translational modification, RNA methylation plays a significant role as an epigenetic mechanism. N6-methyladenosine (m6A) is the most common and abundant methylation modification in RNA molecules present in eukaryotes. 5-methylcytosine (5-mC) also commonly occurs in various RNA molecules. Recent data strongly suggest that m6A and 5-mC RNA methylation affects the regulation of various biological processes such as RNA stability and mRNA translation, and that abnormal RNA methylation contributes to etiology of human diseases.
5-mC RNA Methylation
Study the occurrence of 5-methylcytosine (5-mC) in RNA -- a well-known methylation modification found in various RNA molecules including tRNAs, rRNAs, mRNAs and non-coding RNAs (ncRNAs). Evidence has shown that RNA cytosine methylation affects the regulation of various biological processes such as RNA stability and mRNA translation, and that loss of 5-mC in vault RNAs may cause aberrant processing into Argonaute-associated small RNA fragments that can function as microRNAs.
- MethylFlash 5-mC RNA Methylation ELISA Easy Kit (Fluorometric) For fluorescence-based quantitation of global 5-mC RNA methylation in an ELISA-like format
- EpiNext 5-mC RNA Bisulfite-Seq Easy Kit (Illumina) For RNA bisulfite conversion, followed by a "post-bisulfite" library preparation process
- Methylamp RNA Bisulfite Conversion Kit For robust, chemical-based bisulfite treatment of RNA for methylated cytosine analysis
m6A RNA Methylation
Investigate N6-methyladenosine (m6A) -- the most common and abundant methylation modification in RNA molecules present in eukaryotes. Known as the "fifth RNA base", m6A RNA modifications are reversible, highly dynamic, and likely play important biological roles comparable to DNA methylation and histone modification.
- EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric) For absorbance-based quantitation of N6-methyladenosine in RNA in an ELISA-like format
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