50% OFF NOVUS LOADING CONTROLS INCLUDING Alpha-tubulin, Beta-actin, and GAPDH
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Oct 1 2018
Dec 31 2018
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Tubulin alpha-1A chain (TUBA1A), also known as Alpha-tubulin 3, is the principal alpha tubulin in morphologically differentiated neurons. Alpha tubulin dimerizes with beta Tubulin to form microtubules. Microtubules mediate transport of proteins and endosomes within cells, and TUBA1A has been shown to interact with metabotropic glutamate receptor 7 (receptor trafficking), synuclein alpha (synaptic plasticity), and N-syndecan (neurite outgrowth). This gene is mutated in malformations of cortical development, including Lissencephaly resulting in microcephaly, developmental delay and early-onset epileptic seizures.
Actin makes up the most abundant protein in many eukaryotic cell types. It polymerizes to form microfilaments that have an array of functions, including regulating contractility, motility, cytokinesis, phagocytosis, adhesion, cell morphology, and providing structural support. At least six types of Actin, falling into three categories, exist in higher eukaryotes. The three types, separated based on isoelectric point, include alpha (alpha -Skeletal, alpha -Cardiac, alpha -Smooth Muscle), beta ( beta -Non-muscle) and gamma (gamma -Smooth Muscle, gamma -non-muscle) isoforms. Non-muscle beta - and gamma -actin are also known as cytoplasmic actin.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a 36-40 kDa member of the GAPDH family of enzymes. It is a widely expressed heterotetramer that is found in both the nucleus and cytoplasm. Although GAPDH was initially identified as a glycolytic enzyme that converted G3P into 1,3 diphosphoglycerate, it is now recognized to participate in no less than endocytosis, membrane fusion, vesicular secretory transport, DNA replication and repair, and apoptosis. Human GAPDH is 335 amino acids (aa) in length and contains two NAD binding sites (Asp35 and Asn316) with a catalytic region between aa 151-155. GAPDH contains more than 19 posttranslational modifications, including methylation, deamidation and phosphorylation. One splice variant shows a 10 aa substitution for aa 319-335. Over amino acid 1-150, human GAPDH shares 92% aa identity with mouse GAPDH.
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Note: This offer is to receive select R&D Systems loading controls at 50% off the list price. Discount applies to Universities in Canada only. Discount excludes bulk quantities and special orders. Offer is valid on a one-time order of R&D Systems products placed on or before December 31, 2018. Some exclusions may apply. Offer cannot be used in conjunction with any other offers or discounts, for prior or past purchases, or orders pending. No credits will be issued. All requests are subject to availability and approval by R&D Systems. Offer void where prohibited.