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Anti-Human CD21, Biotin (clone:21A/5) (Mouse IgG1)

Cedarlane
Product Code:
CL7613B
Supplier Name:
Cedarlane
Size:
100 ug
Data Sheet:

View Data Sheet

Categories:
21A/5

Additional Product Details

Applications:
F, C
Clone:
21A/5
Format:
Biotin
Isotype:
Mouse IgG1
Specificity:
CD21
Host:
Mouse
Conjugate:
Biotin
Species Reactivity:
Human
$254.00 CDN


  • Description

    Cedarlane’s anti-Human CD21 monoclonal antibody specifically binds human CD21, also known as Complement component (3d/Epstein Barr virus) receptor 2 (CR2).  CD21 is a protein expressed on mature B cells and follicular dendritic cells, and is weakly expressed on immature thymocytes and T lymphocytes.  CD21 binds to C3d, C3dg, and iC3b in the complement system.  Other ligands include Epstein Barr virus and Interferon alpha.  CD21 plays a role in B cell activation by binding to CD23 and forming a co-receptor complex with CD19, CD81, and Leu13.
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    Flow Cytometry Analysis
    Human peripheral blood lymphocytes were stained with anti-CD21 (clone: 21A/5) (filled histogram) or Mouse IgG1 isotype control (open histogram).
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    Immunofluorescence Analysis

    Purified Anti-Human CD21 (CL7613AP) staining of paraformaldehyde-fixed paraffin-embedded human tonsil sections at 200x (A) and 400x (B) magnification with DAPI counterstain. (Mouse anti-human CD21 mAb (CL7613AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum (blocking)) 

  • References

    1)  CD Guide for CD21 (1989) In Knapp W, et al (eds) Leucocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo, p 1080. ISBN-13: 978-0192618672


    2)  Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. (2009) Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J Biol Chem. 284 (14):9513-20.

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