Anti-Human C5a receptor (CD88), Alexa Fluor®488 (clone 8D6) (rat IgG2a)
DescriptionThis monoclonal antibody detects an epitope on the N terminus (aa 1-15) of the human C5a receptor (also known as CD88) found on human myeloid cells including granulocytes and monocytes/macrophages. It does not bind to tubular epithelial cells in situ under normal or inflammatory conditions. C5aR binds to C5a, a 74 aa peptide cleaved from complement protein C5. C5a receptor has seven transmembrane segments and is a member of the rhodopsin subfamily of G protein coupled receptors.
Applications for this clone include flow cytometry, immunohistochemisty (frozen sections) and receptor blockage assays (unpublished results).______________________________________________________________________________________________________Flow Cytometry AnalysisHuman granulocytes were stained with anti-C5a receptor (CD88) (filled histogram) or rat IgG2a isotype control (open histogram).
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