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Anti-Human C5a receptor (CD88), Alexa Fluor®488 (clone 8D6) (rat IgG2a)

Cedarlane
Product Code:
CL7688AF4
Supplier Name:
Cedarlane
Size:
100 ug
Data Sheet:

View Data Sheet

Categories:
8D6

Additional Product Details

Applications:
F
Clone:
8D6
Format:
Alexa Fluor488
Isotype:
Rat IgG2a
Specificity:
C5a Receptor (CD88)
Host:
Rat
Conjugate:
Alexa Fluor488
Species Reactivity:
Human
$362.00 CDN


  • Description

    This monoclonal antibody detects an epitope on the N terminus (aa 1-15) of the human C5a receptor (also known as CD88) found on human myeloid cells including granulocytes and monocytes/macrophages. It does not bind to tubular epithelial cells in situ under normal or inflammatory conditions. C5aR binds to C5a, a 74 aa peptide cleaved from complement protein C5. C5a receptor has seven transmembrane segments and is a member of the rhodopsin subfamily of G protein coupled receptors.

    Applications for this clone include flow cytometry, immunohistochemisty (frozen sections) and receptor blockage assays (unpublished results).
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    Flow Cytometry Analysis
    Human granulocytes were stained with anti-C5a receptor (CD88) (filled histogram) or rat IgG2a isotype control (open histogram).

  • References

    1)  Kiafard, Z., et al. 2006. Immunobiology, 212:129-139.

    2)  Zwirner, J., et al. 1999. Mol. Immunol. 36:877-884.

    3)  Weinmann, O., et al. 2003. Immunology, 110:458-465.

    4)  Werfel, T., et al. 1996. J. of Immunol., 157:1729-1735.

    5)  Fayyazi, A., et al. 1999. Am. J. Pathol., 154:495-501.

    6)  Werfel, T., et al. 1997. Arch Dermatol. Res., 289:83-86.

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