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SP8

  • Description

    Syntaxin 1 is a 35 KDa integral membrane protein that possesses a single C-terminal transmembrane domain, a SNARE domain (H3) and an N-terminal regulatory domain (Habc). Two isoforms of Syntaxin 1 have been identified, Syntaxin 1A and Syntaxin 1B. Syntaxin 1A localizes to nerve terminals of sensory neurons and nerve fibres reaching small blood vessels. Whereas Syntaxin 1B is localized to motor end plates and  muscle spindles.

    Syntaxin 1A resides at the pre-synaptic membrane and is a key component of the SNARE core complex that also includes Synaptobrevin-2 and SNAP25. Several other proteins including synaptotagmin-1, Munc18-1 and complexin also bind this complex to form the functional SNARE complex. SNARE is responsible for driving secretory vesicle docking, fusion and ultimately exocytosis.
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    Immunofluorescence Analysis


    Purified Anti-Human Syntaxin (CL2707AP) staining of paraformaldehyde-fixed paraffin-embedded human cerebellum sections at 400x magnification with DAPI counterstain. (Mouse anti-human Syntaxin (CL2707AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum (blocking))
       
Product Name: Anti-human syntaxin-1A, Purified, (clone SP8), (Mouse IgG1)
Code:
CL2707AP
Supplier:
Cedarlane
Size:
200ug

40% off SNARE Complex Antibodies
Unit Price:
$439.00 CDN
Your Price:
$263.40 CDN
Product Name: Anti-human syntaxin-1A, Biotin, (clone SP8), (Mouse IgG1)
Code:
CL2707B
Supplier:
Cedarlane
Size:
100ug

40% off SNARE Complex Antibodies
Unit Price:
$277.00 CDN
Your Price:
$166.20 CDN
Product Name: Anti-human syntaxin-1A, FITC, (clone SP8), (Mouse IgG1)
Code:
CL2707F
Supplier:
Cedarlane
Size:
100ug

40% off SNARE Complex Antibodies
Unit Price:
$298.00 CDN
Your Price:
$178.80 CDN
  • References

    1)  De Wit, H et al. Synaptotagmin-1 docks secretory vesicles to Syntaxin-1/SNAP-25 acceptor complexes. Cell. 138, 935-946, 2009.

    2)  Honer, WG et al. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience. 78(1), 99-110, 1997.

    3)  Honer, WG et al. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 609(1-2), 9-20, 1993.

    4)  Honer, WG et al. Monoclonal antibodies to study the brain in schizophrenia. Brain Res. 500(1-2), 379-83, 1989.

    5)  Lang, T. and Jahn R. Core proteins of the secretory machinery. Handb. Exp. Pharmacol. (184): 107-27, 2008.

    6)  Ungermann, C. and Langosch, D. Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing. J. Cell Science. 118, 3819-3828, 2005.

Custom Antibody Services

CEDARLANE® manufactures complement, Lympholyte® cell separation media, cell purification immunocolumns, neuronal cell lines and a wide range of antibodies. CEDARLANE® continues to offer our Custom Antibody Services and increased demand has lead to the continued expansion of our facility. We understand the varied nature of custom work and encourage you to call our qualified staff to discuss the details of your project. Please inquire about other services not listed. Be assured that we at CEDARLANE® are dedicated to ensuring the confidentiality of all projects we discuss.



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