BCELLLOVE APPLIED: 50% OFF THIS PRODUCT
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Jul 2 2019
Jul 31 2019
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Save Big on Tonbo Biosciences Antibodies!
Tonbo Biosciences flow cytometry reagents & antibodies are manufactured with the highest quality and precision and validated for consistent performance in multiparametric flow cytometry experiments. Made in San Diego, CA, our manufacturing process includes optimization of fluorophore to protein ratio (F:P), meticulous quality control testing, and stringent final release criteria, resulting in consistently high-performing reagents for multicolor protocols.
This primary lymphocyte type develops in the bone marrow and circulates in the periphery to provide immune surveillance. B cells recognize antigen via a specific membrane-bound immunoglobulin which acts as a B cell surface receptor (BCR). Activation of the BCR, along with cell surface co-stimulatory molecules including CD19, drives proliferation and development of progeny “plasma” cells that bear and secrete antibodies of identical specificity.
A subset of activated B cells develops into long-lived memory cells, allowing B cells to play a significant role in adaptive immunity. A putative subset of B cells with immune-regulatory function, known as B regulatory (Breg) cells, has been described in humans and in animal models. These cells are able to secrete inhibitory cytokines such as IL-10 and TGF-ß, which act to suppress proliferation of CD4+ T cells and to mediate T regulatory (Treg) cell function via the up regulation of transcription factor Foxp3 and the cell surface co-stimulatory molecule CTLA-4. Breg cells have been identified by flow cytometry based on expression of CD25high CD27high CD86high CD1dhigh IL-10high and TGF-ßhigh.
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Note: This offer is not valid in conjunction with contract discounts or any other special pricing. Void where prohibited. Applies to CD19 and B220 antibodies only. Custom/bulk orders are not eligible. Tonbo reserves the right to modify or cancel this promotion at any time.