PURCHASE ANY ANTIBODY DUO OR PANEL, RECEIVE A FREE MULTIPLEX SECONDARY ANTIBODY PANEL
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Sep 15 2020
Dec 16 2020
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Receive a Free Multiplex Secondary Antibody Panel Today!
Have you noticed a squirrel hidden in the logo of arigo? arigo Biolaboratories use the squirrel as a symbol and aim to provide quality antibodies, antibody duos/panels, and ELISA kits to facilitate scientific research. arigo’s specialty antibody duos or antibody panels offer an all-in-one solution to make research easy and economic. arigo also offers diverse ELISA kits to meet the needs of the emerging research world.
Through this promotion, purchase any arigo Biolaboratories antibody duo or panel and receive a free multiplex secondary antibody panel (Cat. # ARG30338). arigo offers products for a wide range of research areas, including:
- Cell Biology
- and more
HMGB1 is a multifunctional protein with various roles in different cellular compartments. In the nucleus, HMGB1 acts as a DNA-binding protein for gene transcription, gene regulation and DNA repair. In the cytosol, HMGB1 induces autophagy by interacting with Beclin-1 which results in its dissociation from Bcl2 and the subsequent induction of autophagy. In the extracellular compartment, HMGB1 is passively released by necrotic cells and acts as a chemokine and DAMP (Damage-associated molecular pattern) to trigger inflammatory responses. Besides, HMGB1 is also secreted from activated dentric cells and macrophages and functions as a cytokine, it acts as a ligand for RAGE, TLR-2 and TLR-4 thus activating the signal pathways and the following inflammation responses. The HMGB1 released from apoptotic cells is neutralized by reactive oxygen species (ROS)-dependent oxidation and thus promoting immunological tolerance. HMGB1 has attracted the attention of both basic and clinical researchers as its association with various pathologies such as cancer, sepsis, arteriosclerosis, chronic rheumatoid arthritis and nephritis.
arigo offers comprehensive HMGB1 ELISA kits and the best antibodies including HMGB1 neutralizing antibody to facilitate HMGB1-related research.
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Note: This offer is not valid in conjunction with contract discounts or any other special pricing. Void where prohibited.