40% off SNARE Complex Antibodies
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Receive 40% off All Snare Complex Related Antibodies
SNARE proteins are a large protein superfamily consisting of more than 60 members in yeast and mammals. The primary role of these proteins is to mediate fusion of vesicles with their target membrane bound compartments (such as a lysosome). The most well studied SNARE proteins are those involved in mediating synaptic vesicle docking at the pre-synaptic membrane of neurons. During this process syntaxin-1, SNAP-25 and munc18-1 associate and form a complex at the pre-synaptic membrane. This complex interacts with synaptobrevin-2 and synaptotagmin-1 located in synaptic vesicles and initiates docking, priming and fusion at the membrane. This fusion event leads to release of the vesicles cargo into the synaptic cleft, where it can ultimately interact with the post-synaptic neuron.
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