Cedarlane › CL2702AP

Anti-human synaptophysin, Purified, (clone SP15), (Mouse IgM)

$524.00 CDN

Description

Synaptophysin is a 38 KDa synaptic vesicle (SV) glycoprotein containing four transmembrane domains. It is present in SVs of the neuroendocrine system, brain, spinal cord, retina, adrenal medulla and at neuromuscular junctions. synaptophysin acts as a maker for neuroedocrine tumours and has been used to study the distribution of synapses within the brain due to its ubiquity at these regions.

Although the exact function of synaptophysin is still unknown, several lines of evidence suggest it may have multiple important roles in SV exo and endocytosis. These include regulation of SNARE assembly, fusion pore formation initiating neurotransmitter release and activation of SV endocytosis. Additionally, it is thought that synaptophysin may have an important role in SV biogenesis.
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Immunofluorescence Analysis

Purified Anti-Human Synaptophysin (CL2702AP) staining of paraformaldehyde-fixed paraffin-embedded human cerebellum sections at 200x (A) and 400x (B) magnification with DAPI counterstain. (Mouse anti-human Synaptophysin (CL2702AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum (blocking))

References
1) Honer, WG et al. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule inschizophrenia. Neuroscience. 78(1), 99-110, 1997.
2) Honer, WG et al. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 609(1-2), 9-20, 1993.
3) Honer, WG et al. Monoclonal antibodies to study the brain in schizophrenia. Brain Res. 500(1-2), 379-83, 1989.
4) Valtorta, F et al. Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis? Bioessays. 26(4), 445-53, 2004.
5) Young, CE et al. SNAP-25 Deficit and Hippocampal Connectivity in Schizophrenia. Cereb Cortex. 8(3), 261-8, 1998.

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