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Anti-Human CD21/CR2 (Complement Receptor 2), Alexa Fluor647 (clone:21A/5) (Mouse IgG1)
$475.00 CDN
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DescriptionCedarlane’s anti-Human CD21 monoclonal antibody specifically binds human CD21, also known as Complement component (3d/Epstein Barr virus) receptor 2 (CR2). CD21 is a protein expressed on mature B cells and follicular dendritic cells, and is weakly expressed on immature thymocytes and T lymphocytes. CD21 binds to C3d, C3dg, and iC3b in the complement system. Other ligands include Epstein Barr virus and Interferon alpha. CD21 plays a role in B cell activation by binding to CD23 and forming a co-receptor complex with CD19, CD81, and Leu13.______________________________________________________________________________________________________Flow Cytometry Analysis
Human peripheral blood lymphocytes were stained with anti-CD21 (clone: 21A/5) (filled histogram) or Mouse IgG1 isotype control (open histogram).______________________________________________________________________________________________________Immunofluorescence Analysis
Purified Anti-Human CD21 (CL7613AP) staining of paraformaldehyde-fixed paraffin-embedded human tonsil sections at 200x (A) and 400x (B) magnification with DAPI counterstain. (Mouse anti-human CD21 mAb (CL7613AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum (blocking))
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References
1) CD Guide for CD21 (1989) In Knapp W, et al (eds) Leucocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo, p 1080. ISBN-13: 978-0192618672
2) Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. (2009) Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J Biol Chem. 284 (14):9513-20.
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