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Polyclonal (Rabbit)

Description

C1q is part of the C1 complex (C1qr₂s₂) and is the first component of the classical complement pathway. C1q is a glycoprotein with a molecular weight of 410kDa. It has six extended arms with globular domains at the end of each arm that bind to the Fc regions of IgG and IgM. Binding of C1q to surface bound Immunoglobulins triggers activation of the classical complement pathway which ultimately leads to clearance of invading organisms.

C1q deficiency has a profound effect on host defense and has been associated with the development of systemic lupus erythematosus (SLE).
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Flow Cytometry Analysis
Balb/c mouse thymocytes incubated with anti-mouse CD90 (Thy 1.2) (clone: 5a-8) + fresh human serum + 5 mM EDTA were stained with anti-C1q (polyclonal) (filled histogram) or rabbit IgG (open histogram).


	Product Name: Anti-Human Complement Component C1q, Purified, (Polyclonal), (Rabbit IgG) Code: CL7633AP Supplier: Cedarlane Size: 200 ug	Unit Price: $496.00 CDN
	Product Name: Anti-Human Complement Component C1q, Biotin, (Polyclonal), (Rabbit IgG) Code: CL7633B Supplier: Cedarlane Size: 100 ug	Unit Price: $338.00 CDN
	Product Name: Anti-Human Complement Component C1q, HRPO, (Polyclonal), (Rabbit IgG) Code: CL7633HP Supplier: Cedarlane Size: 100 ug	Unit Price: $392.00 CDN

References
1) Klickstein LB., Barbashov SF., Liu T., Jack RM., and Weller AN. 1997. Complement Receptor Type1 (CR1, CD35) is a receptor for C1q. Immunity. 7: 345-355.
2) Eggleton.P., Tenner AJ., and Reid KBM. 2000. C1q receptors. Clin Exp Immunol. 120: 406-412.