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CF-145

Description

Cedarlane’s Anti-Human Calgranulin A monoclonal antibody reacts with the human Calgranulin A protein. Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma. We also sell an anti-human Calgranulin B monoclonal antibody, Clone CF-557 (CL2712AP, B and F).
Reported applications of this antibody include flow cytometry, IF, IHC and Western blots.
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Flow Cytometry Analysis
Human whole blood (granulocyte population) stained with anti-human calgranulin A (clone: CF-145) (filled histogram) or mouse IgG2b isotype control (open histogram).


	Product Name: Anti-Human Calgranulin A (S100A8), Purified (Clone CF-145) (mouse IgG2b) Code: CL2711AP Supplier: Cedarlane Size: 200 ug	Unit Price: $372.00 CDN
	Product Name: Anti-Human Calgranulin A (S100A8), Biotin (Clone CF-145) (mouse IgG2b) Code: CL2711B Supplier: Cedarlane Size: 100 ug	Unit Price: $282.00 CDN
	Product Name: Anti-Human Calgranulin A (S100A8), FITC (Clone CF-145) (mouse IgG2b) Code: CL2711F Supplier: Cedarlane Size: 100 ug	Unit Price: $306.00 CDN

References
1) Klein et al. 1996. Identification and Functional Separation of Retinoic Acid Receptor Neutral Antagonists and Inverse Agonists. The Journal of Biological Chemistry Sept; 271(37):22692-22696.
2) Nagpal et al. 1996. Negative Regulation of Two Hyperproliferative Keratinocyte Differentiation Markers by a Retinoic Acid Receptor-specific Retinoid: Insight into the Mechanism of Retinoid Action in Psoriasis. Cell Growth and Differentiation Dec; 7:1783-1791.
3) Thacher et al. 1999. Cell Type and Gene-specific Activity of the Retinoid Inverse Agonist AGN 193109: Divergent Effects from Agonist at Retinoic Acid Receptor γ in Human Keratinocytes. Cell Growth and Differentiation Apr; 10:255-262.