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  • Hypothalamic Cell Lines

    • Neuropeptide Y stimulates autophagy in hypothalamic neurons.
    • Aveleira CA, Botelho M, Carmo-Silva S, et al.
    • Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1642-51.
    • PMID: 25775546
    • Depolarization of surface-attached hypothalamic mouse neurons studied by acoustic wave (thickness shear mode) detector.
    • Cheung S, Fick LJ, Belsham DD, Thompson M.
    • Analyst. 2010 Feb;135(2):289-95. Epub 2009 Dec 21.
    • PMID: 20098760
    • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation.
    • Mayer CM, Belsham DD.
    • Endocrinology. 2010 Feb;151(2):576-85. Epub 2009 Dec 1.
    • PMID: 19952270
    • Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation.
    • Mayer CM, Belsham DD.
    • Endocrinology. 2010 Jan;151(1):75-84. Epub 2009 Nov 3.
    • PMID: 19887566
    • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons.
    • Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM.
    • FASEB J. 2009 Dec;23(12):4256-65. Epub 2009 Aug 24.
    • PMID: 19703933
    • Rac1 and Rac2 in osteoclastogenesis: a cell immortalization model.
    • Wang Y, Belsham DD, Glogauer M.
    • Calcif Tissue Int. 2009 Sep;85(3):257-66. Epub 2009 Aug 2.
    • PMID: 19649754 [PubMed - indexed for MEDLINE] Related articles 6.
    • Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons.
    • Mayer CM, Belsham DD.
    • Mol Cell Endocrinol. 2009 Aug 13;307(1-2):99-108. Epub 2009 Mar 14.
    • PMID: 19524132
    • -highlights N-46
    • The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons.
    • Gingerich S, Wang X, Lee PK, Dhillon SS, Chalmers JA, Koletar MM, Belsham DD.
    • Neuroscience. 2009 Sep 15;162(4):1134-40. Epub 2009 May 20.
    • PMID: 19463905
    • Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons.
    • Dhillon SS, Gingerich S, Belsham DD.
    • Regul Pept. 2009 Aug 7;156(1-3):96-103. Epub 2009 Apr 14.
    • PMID: 19371763
    • -highlights N-38
    • Hypothalamic cell lines to investigate neuroendocrine control mechanisms.
    • Mayer CM, Fick LJ, Gingerich S, Belsham DD.
    • Front Neuroendocrinol. 2009 Aug;30(3):405-23. Epub 2009 Mar 31. Review.
    • PMID: 19341762
    • Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons.
    • Fick LJ, Cai F, Belsham DD.
    • Neuroendocrinology. 2009;89(3):267-75. Epub 2008 Oct 29.
    • PMID: 18957841
    • Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1.
    • Madadi G, Dalvi PS, Belsham DD.
    • Biochem Biophys Res Commun. 2008 Nov 28;376(4):694-9. Epub 2008 Sep 20.
    • PMID: 18809381
    • Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons.
    • Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD.
    • J Neurosci. 2008 Jun 18;28(25):6473-82.
    • PMID: 18562618
    • Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.
    • Wauman J, De Smet AS, Catteeuw D, Belsham D, Tavernier J.
    • Mol Endocrinol. 2008 Apr;22(4):965-77. Epub 2007 Dec 28.
    • PMID: 18165436
    • Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation.
    • Cheng H, Isoda F, Belsham DD, Mobbs CV.
    • Endocrinology. 2008 Feb;149(2):703-10. Epub 2007 Nov 1.
    • PMID: 17974626
    • -highlights N-38
    • Hormonal regulation of clonal, immortalized hypothalamic neurons expressing neuropeptides involved in reproduction and feeding.
    • Belsham DD.
    • Mol Neurobiol. 2007 Apr;35(2):182-94.
    • PMID: 17917107
    • Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells.
    • Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA.
    • Brain Res. 2007 Oct 24;1176:27-36. Epub 2007 Aug 22.
    • PMID: 17900539
    • Adipokine gene expression in a novel hypothalamic neuronal cell line:
    • resistin-dependent regulation of fasting-induced adipose factor and SOCS-3.
    • Brown R, Imran SA, Belsham DD, Ur E, Wilkinson M.
    • Neuroendocrinology. 2007;85(4):232-41. Epub 2007 Jun 19.
    • PMID: 17579277
    • Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin.
    • Cai F, Gyulkhandanyan AV, Wheeler MB, Belsham DD.
    • J Endocrinol. 2007 Mar;192(3):605-14.
    • PMID: 17332528
    • -highlights N-43/5
    • Label-free detection of neuron-drug interactions using acoustic and Kelvin vibrational fields.
    • Cheran LE, Cheung S, Al Chawaf A, Ellis JS, Belsham DD, MacKay WA, Lovejoy D, Thompson M.
    • Analyst. 2007 Mar;132(3):242-55. Epub 2007 Jan 18.
    • PMID: 17325758
    • Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1.
    • Al Chawaf A, St Amant K, Belsham D, Lovejoy DA.
    • Neuroscience. 2007 Feb 23;144(4):1241-54. Epub 2006 Dec 15.
    • PMID: 17174479
    • Regulation of hypthalamic expression of KiSS-1 and GPR54 genes by metabolic factors: Analyses using mouse models and a cell line.
    • Luque, R., M., Dineman, R., D., and Tena-Sempere, M.
    • 2007. Endocrinology Vol. 148: 4601-4611.
    • -highlights N-6
    • Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1.
    • Cui H, Cai F, Belsham DD.
    • FASEB J. 2006 Dec;20(14):2654-6. Epub 2006 Oct 31.
    • PMID: 17077290
    • Functional cross-modulation between SOCS proteins can stimulate cytokine signaling.
    • Piessevaux J, Lavens D, Montoye T, Wauman J, Catteeuw D, Vandekerckhove J, Belsham D, Peelman F, Tavernier J.
    • J Biol Chem. 2006 Nov 3;281(44):32953-66. Epub 2006 Sep 6.
    • PMID: 16956890
    • Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons.
    • Titolo D, Cai F, Belsham DD.
    • Mol Endocrinol. 2006 Sep;20(9):2080-92. Epub 2006 May 4.
    • PMID: 16675543
    • -highlights N-38
    • Leptin signaling in neurotensin neurons involves STAT, MAP kinase ERK1/2, and p38 through c-Fos and ATF1.
    • Cui, H. Cai, F., and Belsham, D. D.
    • 2006. The FASEB Journal. 20:E2268-E2276.
    • -highlights N-39
    • Ghrelin and cannabinoids increase food intake via stimulation of the hypothalamic amp-activated protein kinase (AMPK).
    • Adams, VC., Kola, B., Garcia, E., Hubina, E., Dalino, P., Khalaf, S., Grossman, A., and Korbonits, M.
    • 2005. Endocrine Abstracts 10, OC6
    • -highlights N-39
    • Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders.
    • Belsham, D. D., Cai, F., Smuckler, S. R., Salapatek, A. M. F., and Shkreta, L.
    • 2004. Endocrinology. 145(1): 339-400.
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