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Cedarlane › Reagents › Cedarlane Manufactured › Reagents For Human › Miscellaneous Antibodies › Tamm Horsfall (Uromucoid) › 10.32

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CEDARLANE® manufactures Complement, Lympholyte® cell separation media, cell purification Immunocolumns and a wide range of Antibodies. Also, CEDARLANE® continues to offer our Custom Antibody Services.

  

Cedarlane-manufactured Reagents

Our line of Cedarlane-manufactured reagents.

10.32

  • Description

    Cedarlane anti-human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kDa containing up to 25% carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by adult humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy.

    CL1032AP can be used in indirect immunosorbent enzyme assays or in immunohistopathology for staining of frozen sections and formalin fixed, paraffin embedded tissues by indirect immunofluorescence or immunoperoxidase. It can also be used to purify THP by binding to a solid phase. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins. This antibody also works with canine tissue.
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    Immunohistochemical Analysis


    IHC staining of formalin-fixed, paraffin-embedded human tissue (kidney) using Purified Anti-Human Tamm Horsfall (CL1032AP) at a dilution of 20 μg/mL.
       
Product Name: Anti-Human Tamm Horsfall Ascites (Clone 10.32) (mouse IgG2b)
Code:
CL1032A
Supplier:
Cedarlane
Size:
1ml
Unit Price:
$524.00 CDN
Product Name: Anti-Human Tamm Horsfall Purifed (Clone 10.32) (mouse IgG2b)
Code:
CL1032AP
Supplier:
Cedarlane
Size:
250ug
Unit Price:
$456.00 CDN
Product Name: Anti-Human Tamm Horsfall FITC (Clone 10.32) (mouse IgG2b)
Code:
CL1032F
Supplier:
Cedarlane
Size:
100ug
Unit Price:
$382.00 CDN
Product Name: Anti-Human Tamm Horsfall, HRPO (Clone 10.32) (mouse IgG2b)
Code:
CL1032HP
Supplier:
Cedarlane
Size:
100ug
Unit Price:
$456.00 CDN

  • References

    1) Bhagavan, B.S., R.E. Wenk and D. Dutta. 1979. Pathways of Urinary Backflow in Obstructive Uropathy. Human Pathology. 10: 669-683.

    2) McKenzie, J.K., and E.G. McQueen. 1969. Immunofluorescent localization or Tamm-Horsfall mucoprotein in human kidney. J. Clin. Path. 22:334-339.

    3) Zager, R.A., R.S. Cotran & J.R. Hoiyer. 1978. Pathologic Localization of Tamm-Horsfall Protein in Interstitial Deposits in Renal Disease. Lab Invest. 38: 52-57.

    4) Nanus, D.M., et al. 1989. Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression. J. Exp. Med. 69: 953-972.

    5) Nagashima, Y. et al. 2005. Renal oncocytosis. Pathology International. 55: 210-215.

    6) Howell, D.N., et al. 1991. Characterization of a novel human corneal endothelial antigen. Investigative Ophthalmology and Visual Science, 32: 2473-2482.

Custom Antibody Services

CEDARLANE® manufactures complement, Lympholyte® cell separation media, cell purification immunocolumns, neuronal cell lines and a wide range of antibodies. CEDARLANE® continues to offer our Custom Antibody Services and increased demand has lead to the continued expansion of our facility. We understand the varied nature of custom work and encourage you to call our qualified staff to discuss the details of your project. Please inquire about other services not listed. Be assured that we at CEDARLANE® are dedicated to ensuring the confidentiality of all projects we discuss.



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