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Cedarlane › Reagents › Cedarlane Manufactured › Specialty Products › FLAER

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CEDARLANE® manufactures Complement, Lympholyte® cell separation media, cell purification Immunocolumns and a wide range of Antibodies. Also, CEDARLANE® continues to offer our Custom Antibody Services.

  

Cedarlane-manufactured Reagents

Our line of Cedarlane-manufactured reagents.

FLAER

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    FLAER Alexa Fluor® 488 Proaerolysin

    Cedarlane offers FLAER Alexa Fluor® 488 proaerolysin, Used as a flow cytometry reagent for PNH (Paroxysmal Nocturnal Hemoglobinuria) diagnosis and research.FLAER is an Alexa Fluor®488 labelled inactive variant of aerolysin, a unique protein that binds tightly and specifically to mammalian GPI anchors. FLAER does not bind to PNH cells. It is this reliable absence of FLAER binding to GPI anchor deficient cells that allows this reagent to efficiently detect leukocyte PNH clones. Before FLAER, detection of PNH clones by flow cytometry relied on fluorescent labeled antibodies to GPI-linked proteins such as CD59(MIRL) and DAF(CD55).

    Key Features:

    Highly Specific GPI Anchor Binding - Binds tightly and directly to glycosylphosphatidylinositol (GPI) anchors on mammalian cell surfaces.
    Superior Sensitivity vs. Traditional Methods - More sensitive than CD59 and CD55 antibodies; even very small PNH clone populations can be detected that would be missed by conventional antibody-based methods.
    Reduced Risk of False Negatives - Traditional antibodies screen for loss of a specific protein (e.g., CD59 or CD55), leaving room for false negatives. FLAER targets the GPI anchor itself - if the anchor is absent, cells are FLAER-negative.
    Validated for Multi-Parameter Flow Cytometry - Used alongside antibodies (CD45, CD33, CD24, CD15, CD14) to detect PNH clones in monocyte and granulocyte lineages per clinical guidelines.
    Available in Two Formats - Offered in both liquid and lyophilized formats for lab flexibility.
    Human peripheral blood leukocytes flow cytometry graphs

    Human peripheral blood leukocytes were stained with FLAER (Alexa 488 proaerolysin variant) (right). Unstained cells are shown in the left plot.

    Featured Products:

    Format Size # of Tests Product
    Liquid 25 µg 50 FL1S-C
    50 µg 100 FL2S-C
    Format Size # of Tests Product
    Lyophilized 25 µg 50 FL1-C
    50 µg 100 FL2-C

    FLAER is sold as an In Vitro Diagnostic (IVD) reagent in Canada and Europe.
    Alexa Fluor® is a registered trademark of Molecular Probes, Inc., which is a subsidiary of Thermo Fisher Scientific Inc.

    Canada and Europe FLAER Brochure

    For More Information

    Learn more about FLAER Alexa Fluor® 488 proaerolysin, its key features, available formats and ordering information.

    Download Brochure Now
       
Product Name: FLAER (Alexa 488 proaerolysin variant) solid format-IVD
Code:
FL1-C
Supplier:
Cedarlane
Size:
25 ug
Unit Price:
$396.00 CDN
Product Name: FLAER (Alexa 488 proaerolysin variant) liquid format-IVD
Code:
FL1S-C
Supplier:
Cedarlane
Size:
25 ug
Unit Price:
$396.00 CDN
Product Name: FLAER(Alexa 488 proaerolysin variant) solid format-IVD
Code:
FL2-C
Supplier:
Cedarlane
Size:
50 ug
Unit Price:
$655.00 CDN
Product Name: FLAER (Alexa 488 proaerolysin variant) liquid format-IVD
Code:
FL2S-C
Supplier:
Cedarlane
Size:
50 ug
Unit Price:
$655.00 CDN

Custom Antibody Services

CEDARLANE® manufactures complement, Lympholyte® cell separation media, cell purification immunocolumns, neuronal cell lines and a wide range of antibodies. CEDARLANE® continues to offer our Custom Antibody Services and increased demand has lead to the continued expansion of our facility. We understand the varied nature of custom work and encourage you to call our qualified staff to discuss the details of your project. Please inquire about other services not listed. Be assured that we at CEDARLANE® are dedicated to ensuring the confidentiality of all projects we discuss.



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