Canada
United States
International
Anti-Human CD163, APC (clone: GHI/61) (mouse IgG1,k)
|
Product Code:
|
CL7617APC |
|
Supplier Name:
|
Cedarlane |
|
Size:
|
100 ug |
|
Data Sheet:
|
View Data Sheet |
|
Categories:
|
GHI/61 |
Additional Product Details
|
Applications:
|
F |
|
Clone:
|
GHI/61 |
|
Format:
|
APC |
|
Isotype:
|
Mouse IgG1,k |
|
Specificity:
|
CD163 |
|
Host:
|
Mouse |
|
Conjugate:
|
Allophycocyanin |
|
Species Reactivity:
|
Human |
$593.00 CDN
-
DescriptionCedarlane’s Anti-Human CD163 monoclonal antibody binds CD163, also known as haemoglobin scavenger receptor and M130. This receptor is a membrane glycoprotein of 130 kDa and is found during the late stages of inflammation exclusively on the surface of human monocytes and macrophages. CD163 is a member of the scavenger receptor cysteine-rich family, and is a receptor for the haemoglobin-haptoglobin complex.______________________________________________________________________________________________________Immunofluorescence Analysis
Purified Anti-Human CD163 (CL7617AP) staining of paraformaldehyde-fixed paraffin-embedded human spleen sections at 400x magnification (A) and human tonsil sections at 200x (B) 400x (C) magnification with DAPI counterstain. (Mouse anti-human CD163 mAb (CL7617AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum (blocking))Flow Cytometry Analysis
Human peripheral blood monocytes were stained with anti-CD163 (clone: GHI/61) (filled histogram) or mouse IgG1 isotype control (open histogram).
-
References
1) Pulford K, Micklem K, McCarthy S, et al. A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology. 75(4):588-95. 1992.
2) Law SK, Micklem KJ, Shaw JM, et al. A new macrophage differentiation antigen which is a member of the scavenge receptor superfamily. Eur J Immunol. 23(9):2320-5. 1993.
3 Møller HJ, Peterslund NA, Graversen JH, Moestrup SK. Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma. Blood. 99(1):378-80. 2002.
4) Moniuszko M, Kowal K, Rusak M, et al. Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants. Clin Vaccine Immunol. 13(6):704-7. 2006.
No promotions are currently being offered by this supplier.
