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Bovine Trabecular Meshwork

  • Spontaneously Immortalized Bovine Trabecular Meshwork Cell Line (BTM-28T)

    BTM-28T represents a spontaneously immortalized cell line derived from primary bovine trabecular meshwork (BTM) cell cultures isolated from tissue dissected from calf eyes. This cell line is seen to be morphologically similar to primary trabecular meshwork cells while proliferating at a much higher rate through a high number of passages. BTM-28T exhibits contact inhibition properties, enabling maintenance at 100% confluency under high glucose conditions. It is also seen to express the trabecular meshwork cell markers alpha-smooth muscle actin, laminin, and collagen IV. Furthermore, induction of cross-linked actin networks by dexamethasone is observed in BTM-28T, a behavior typically observed in primary TM cells.

    The BTM-28T cell line represents a unique and valuable research tool for ophthalmic and glaucoma researchers in academia and industry. It will help better understand the aqueous humor outflow pathway as related to the pathophysiology of glaucoma.

    Further details regarding this cell line can be found in the following paper:

    The datasheet for these products can be downloaded here.

    Supplementary Figures



    BTM-28T cells expressed TM cell markers including α-SMA (A), Collagen IV (B) and Laminin (C), respectively (DAPI counterstained nuclei in blue). (D) Dexamethasone (DEX) induced cross-linked actin network (CLAN) formation in BTM-28T cells: Morphology of CLANs (circled area). Green (pseudocolor): phalloidin staining; blue: DAPI staining.

       
Product Name: Spontaneously Immortalized Bovine Trabecular Meshwork Cell Line (BTM-28T)
Code:
CLU511
Supplier:
Cedarlane
Size:
1 mL
Extra Notes:
Please inquire for pricing. MTA required.
Unit Price:
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Custom Antibody Services

CEDARLANE® manufactures complement, Lympholyte® cell separation media, cell purification immunocolumns, neuronal cell lines and a wide range of antibodies. CEDARLANE® continues to offer our Custom Antibody Services and increased demand has lead to the continued expansion of our facility. We understand the varied nature of custom work and encourage you to call our qualified staff to discuss the details of your project. Please inquire about other services not listed. Be assured that we at CEDARLANE® are dedicated to ensuring the confidentiality of all projects we discuss.