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InVivoMAb anti-mouse IL-23 (p19)
The G23-8 monoclonal antibody reacts with the p19 subunit of mouse IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. The G23-8 antibody can specifically neutralize IL-23 bioactivity with no effect on IL-12 p70 bioactivity.
Bio X Cell has been supplying the research community for over 20 years with bulk amounts of monoclonal antibodies. It is Bio X Cell’s commitment to provide highest quality monoclonal antibodies at lowest prices for in-vitro and in-vivo preclinical animal studies
Bio X Cell understands the strict quality criteria required for such studies and the financial limitations faced by many researchers. Bio X cell’s antibodies are:
- Ultra-low in endotoxin
- No Azide, other preservatives or protein stabilizers
- InVivoPlus is free of murine pathogens
- Protein aggregates < 5%
- Highly competitive prices
Bio X Cell’s portfolio of antibodies, including isotype controls, features the most relevant and best researched antibodies on the market. Bio X Cell also offers custom antibody production/purification services.
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