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ATCC Cell Lines and Culture

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  • American Type Culture Collection is a long-standing organization established in 1925, and is dedicated to a wide range of practices. As a biological resource center, ATCC authenticates microorganisms and cell lines, and also manages logistics of long-term preservation and distribution of cultures for a robust scientific community. ATCC is committed to supporting the cultures it acquires and authenticating with expert technical support, intellectual property management and characterization data. American Type Culture Collection is known for their most diverse collection of biological research solutions.

    Leading Medical Research & Biological Materials Management

    As a research organization, ATCC works to produce innovative knowledge and technology, as well as to consistently improve its function as a BRC. ATCC scientists develop new in vitro model systems, outline new species, search for new disease biomarkers, and shape bodies of characterization data for valuable biological materials. American Type Culture Collection has a vast microorganism collection that includes 3,000 different types of animal viruses and various strains used for vaccine development. The organization is fundamentally dedicated to utilizing its resources and experience as a BRC to be the recognized leader in biological reference materials – particularly in the acquisition of new content, development of reference standards using unique assets, and through inquiry as to how biological research can be wholly improved through standardization and certification of biological materials. ATCC offers specialized and custom services as a biological resource center where customers can reserve opt for a safe deposit service for their own cell cultures. Those who use ATCC products and services nationally or internationally are primarily researchers in academia and governmental services. The organization exercises considerable dedication throughout all of its practices in adhering to, upholding and exceeding industry standards regarding ethics, intellectual property, management and corporate responsibility. These initiatives encompass a wide range of products and services and are the vital imperatives upon which American Type Culture Collection is constructed and operates.

    Product Types:

    • Cells and Microorganisms
    • Culture Reagents
    • Testing and Characterization
    • Quality Control Stains
    • Nucleic Acids & Toxins

    Reporter-Labeled Strains – Powerful Tools for Microbiology Research

    Click here to download the ATCC White Paper for Reporter-Labeled Strains. This paper discusses the reporters commonly used in microbiological research, and delves into further detail on the various applications of reporter-labeled strains.

  • ATCC Learning Center

    The ATCC Learning Center provides researchers with tangible resources for advancing and supporting their research. This includes the latest ATCC newsletters, upcoming webinar registration information, product sheets, and much more! Click here to access these valuable resources!

    ATCC® Standards Development Organization Releases Third ANSI Standard

    ATCC Standards Development Organization released its third ANSI Standard: Species‐Level Identification of Animal Cells through Mitochondrial Cytochrome c Oxidase Subunit 1 (CO1) DNA Barcodes (ANSI/ASN‐0003‐2015) for interspecies cell line identity based on sequence technology. This new standard complements the existing standard, ASN-0002- Authentication of Human Cell Lines: Standardization of STR Profiling, which is used for human cell line and tissue identification.

    Click here for more information.

    ATCC Webinars

    Explore the expanding collection of ATCC webinars to learn more about the innovative research and development being performed by thought leaders in science.Click here to access these webinars!

  • Save 10% on ATCC

    Primary Product Categories

    • Cells and Microorganisms
    • Disease/Model
    • Tissue
    • Tumor Cell Panels
    • Microbial Panels
    • Primary Cells
    • Stem Cells
    • Culture Reagents
    • Buffers and Stains
    • Media

    ATCC is a private, non-profit biological resource center (BRC) and research organization, focused on the acquisition, authentication, production, preservation, development and distribution of standard reference microorganisms, cell lines, cell culture, and other materials for research in the life sciences. As a long established entity in the field of life science, ATCC is a reliable and well-known name providing similar high-level products and services. Cedarlane is happy to distribute ATCC’s extensive product range with particular emphasis on affordability and efficiency.

  • Easy-to-Follow Culture Guides

    Culturing biological materials can be challenging at times even for the expert culturist. With nearly a century of expertise with cell and microbial cultures, ATCC has acquired and developed a vast body of best practices to aid researchers at all levels of proficiency to maximize the return on their biomaterials investment. The guides below deliver that knowledge and insight to the end user in a portable, easy-to-follow format.
  • Thousands of Authenticated Reference Genomes - ATCC Genome Portal

    Over the past few years, ATCC has been working toward providing authenticated whole-genome sequences of our microbial collection via the ATCC Genome Portal. We recently reached a new milestone in our journey. We now have more than 4,000 genomes available on the portal! We are the only authenticated reference genome database for ATCC microbes

    Changes to ATCC Genome Portal access

    Thank you for your continued support as we have grown the ATCC Genome Portal to include over 4,100 reference genomes. Please note some changes to our ATCC Genome Portal service. As you know, we have been providing access to the ATCC Genome Portal to you free of charge. However, to ensure the long-term sustainability of the portal, and so that we can continue to provide you with reference-quality genomes, we are transitioning the ATCC Genome Portal to a supporting membership service starting May 1, 2024.

    With a supporting membership to the ATCC Genome Portal, you will have access to all the features and benefits you experience now in addition to all future extended capabilities such as bulk download options, Discrepancy Reports, and more. If you choose not to pursue a supporting membership, you will still have access to the genomic data for strains you purchase from ATCC as well as the ability to search for and view genomes of interest on the ATCC Genome Portal.

    We appreciate your patience and understanding during this transition. For more details about this change, please visit online. If you have any questions or would like to provide us with feedback, please don't hesitate to contact us at nextgen@atcc.org.

  • ATCC Cell Line Land Webinar

    Enhance Your Research with the ATCC Cell Line Land Webinar

    Unlock the full potential of your research with insights from the recorded webinar "ATCC Cell Line Land: Reference-Quality RNAseq Data from Credible ATCC Cell Lines".

    In this comprehensive webinar, industry experts delve into:

    • The Importance of Credible Cell Lines: Understand why using authentic ATCC cell lines is crucial for reliable research outcomes.
    • Reliable and Authentic RNAseq Data: Learn how ATCC ensures the highest quality and reliability in their RNAseq data.
    • Practical Applications: Discover how RNAseq data can be applied across various fields of study to enhance your research.

    Watch the Webinar Recording:

    Title: ATCC Cell Line Land: Reference-Quality RNAseq Data from Credible ATCC Cell Lines
    Link: Watch the Recording

    Don't miss this opportunity to learn from the best and leverage ATCC's trusted resources to take your research to the next level. Watch the recording today!

  • News

    ATCC and USP Enter Strategic Collaboration to Support Global Quality Production of Biologics

    Manassas, VA, February 2023 - ATCC and USP to provide solutions and standards to help customers deliver safe and high-quality biologics to patients more rapidly. ATCC, the world’s premier biological materials management and standards organization and U.S. Pharmacopeia (USP), an independent, international, and scientific nonprofit organization, today announced a long-term, multi-year strategic collaboration to jointly provide co-branded reference materials and reference standards that will serve to advance the quality and development of biologic medicines and therapies. Read more.

    ATCC Announces Award from Leidos Biomedical Research for the Production and Distribution of Next-generation Cancer Models

    January, 2022 — ATCC, the world’s premier biological materials management and standards organization, today announced that it has been awarded a contract with Leidos Biomedical Research, Inc. (Leidos Biomed), current operator of the Frederick National Laboratory for Cancer Research, for the continued production, characterization and distribution of next-generation cancer models (NGCM). These models will be distributed solely by ATCC as part of the National Cancer Institute’s (NCI) Human Cancer Model Initiative (HCMI), an international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic, clinical and biospecimen data. In consultation with the HCMI team at Leidos Biomed and the Center for Cancer Genomics (CCG) at NCI, the contract will add 70 additional NGCMs to HCMI’s current catalog of 182 models – all of which will be available as a community resource through its data portal. Read more.

  • Monthly Feedback Draw

    NEW Genomic DNA Control Materials for Measurement of Residual DNA - ATCC-USP Collaboration

    Analytical Reference Materials for Residual Host Cell DNA Testing

    Regulators require that manufacturers demonstrate the removal of genomic DNA from biological therapies and vaccines since it can pose a safety risk if it is not purified from the product. As biopharmaceutical innovation continues to advance, trusted reference materials and standards can help accelerate biologics development.

    ATCC and USP have come together to offer solutions that help ensure the quality of cell and gene therapies, vaccines, and recombinant proteins. The initial set of six products consists of highly characterized and pure genomic DNA (gDNA) from cell lines used in bioproduction that can be used to measure residual host cell DNA.

    These products and materials support the most common platforms used in the rapidly growing cell and gene therapy and vaccines sectors:

    • Quantitative HEK-293 Genomic DNA
    • Quantitative Sf9 Genomic DNA
    • Quantitative Vero Genomic DNA
    • Quantitative MDCK Genomic DNA
    • Quantitative MRC-5 Genomic DNA
    • Quantitative BHK-21 Genomic DNA

    Click here to learn more about these high-quality reference materials.

    For more about the ATCC-USP collaboration, visit here.

  • Next Generation Cancer Models

    ATCC HCMI Cell Models

    ATCC is excited to provide the HCMI models, which include both common as well as rare and understudied examples of cancer from numerous tissues. These HCMI models are valuable tools to study cancer, identify and target novel therapies, and facilitate translational cancer research. To enhance their clinical relevance, the sequence data and patient clinical information for each model is available to the research community. Explore the Collection

    ATCC Organoid Growth Kit

    Organoids are valuable tools to study cancer, identify and target novel therapies, and facilitate translational cancer research. These 3-D models are becoming more relevant because they are predictive of the in vivo tumor microenvironment. In efforts to simplify Organoid culture, ATCC has developed Organoid Growth Kits which comprise single-use supplements created to streamline media preparation. These kits contain the most costly and cumbersome supplements and reagents, reducing the time and effort required to prepare media and ensuring the successful growth of your organoids. Explore the Collection.

  • FEATURED PRODUCTS

  • Save on ATCC Products through Cedarlane
    ATCC®Genomic RNA isolated from a preparation of Severe acute respiratory syndrome-related coronavirus 2 isolate USA/MD-HP05285/2021. This product can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load.


    Save on ATCC Products through Cedarlane
    This product is a whole-genome sequenced preparation of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) strain 2019-n-CoV/USA-WA1/2020 that has been inactivated by heating. This strain was originally isolated from a human case in Washington state and was deposited by the Centers for Disease Control and Prevention. This product is intended for use in molecular assays or as a process control (eg, viral RNA extraction through qPCR amplification process), and it can also be used to make a dilution series to estimate level of detection.

    Save on ATCC Products through Cedarlane
    This product is a preparation of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) strain USA/MD-HP05285/2021 (Delta variant) that has been inactivated by heating at 65°C for 30 minutes and is therefore unable to replicate. This heat-inactivated preparation is whole-genome sequenced and can be used as a process control in the development of SARS-CoV-2 molecular diagnostic tools and can also be used to make a dilution series to estimate the level of detection. Due to the dynamic nature of lineage determination using PANGO, it is recommended to confirm the provided GISAID information prior to initiation of work

    Save on ATCC Products through Cedarlane
    A vial of heat-inactivated SARS-CoV-2 variant B.1.351 (Beta). This strain was isolated from a clinical specimen in Maryland and deposited by the CDC.

  • Save on ATCC Products through Cedarlane
    ATCC®VR-3326HK is a preparation of SARS-CoV-2 strain USA/CA_CDC_5574/2020 (Alpha variant) that has been inactivated by heating. The strain was isolated in December 2020 from a nasopharyngeal swab from a human in San Diego, California, and was deposited by the Centers for Disease Control and Prevention. This heat-inactivated preparation is whole-genome sequenced and can be used as a process control in the devleopment of SARS-CoV-2 molecular diagnostic tools and can also be used to make a dilution series to estimate the level of detection.


    Save on ATCC Products through Cedarlane
    Genomic RNA isolated from a preparation of Severe acute respiratory syndrome-related coronavirus 2 strain 2019-nCoV/USA-WA1/2020. This product can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load.

    Save on ATCC Products through Cedarlane
    This product is a preparation of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) strain USA/COR-22-063113/2022 (Omicron variant) that has been inactivated by heating at 65°C for 30 minutes and is therefore unable to replicate. This heat-inactivated preparation is whole-genome sequenced and can be used as a process control in the development of SARS-CoV-2 molecular diagnostic tools and can also be used to make a dilution series to estimate the level of detection.

  • Reporter-labeled Cells

    Reporter-labeled Cells

    Reporter-labeled cell lines are invaluable research tools for studying gene expression and for screening cell lines. Some of the most commonly used reporter systems are those that induce a visually identifiable phenotype such as the emission of fluorescent or luminescent light or the production of a pigmented product. Fluorescent reporters exhibit a fluorescent signal upon exposure to specific wavelengths of light; luminescent reporters use a luciferase enzyme to catalyze a reaction with its substrate, luciferin, to produce visible light; and chromogenic reporters employ an enzyme label that reacts with a substrate to produce a pigmented product.

    Advantages of Reporter-labeled Cultures

    Reporter systems have an array of applications in the basic and applied sciences. In biological research, reporter systems provide a measurable and distinguishable phenotype that can be applied in the analysis of:

    • Quantification
    • Detection
    • Host-pathogen interactions
    • Drug discovery
    • Compound screening
    • Toxicity studies
    • In vivo imaging
    • Quality control
    • Pathway research
    • Differentiation studies

Still Need More Help?

If you have sales questions relative to particular products or to your line of research, please contact the CEDARLANE® sales department and have all of your questions answered in a timely and professional manner.

     
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