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Featured Dianova Antibodies
Anti-murine CD31 (PECAM-1) in formalin-fixed paraffin sections
Clone SZ31: The first antibody clone that specifically reacts with muring CD31 (PECAM-1) in formalin-fixed paraffin-embedded tissues. CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed on the surface of embryonic and adult endothelial cells. CD31 is a 130kDa integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Until now pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were problematic. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.
Figure: courtesy of Prof.Dr.H.Stein, Institute of Pathology, Charité Campus Benjamin Franklin, Berlin, Germany)
Anti-IDH1 R132H (Hu) from Mouse (Clone: H09)
Antibody clone H09 reacts specifically with the isocitrate dehydrogenase 1 (IDH1) R132H point mutation in tissue sections from formalin-fixed brain tumor. Heterozygous point mutations of IDH1 codon 132 are frequent in World Health Organization (WHO) grade II and III gliomas. IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. The high frequency and distribution of the IDH1 R132H mutation among specific brain tumor entities allow the highly sensitive and specific discrimination of various tumors by immunohistochemistry, such as anaplastic astrocytoma from primary glioblastoma or diffuse astrocytoma WHO grade II from pilocytic astrocytoma or ependymoma. Noteworthy is the discrimination of the infiltrating edge of tumors with IDH1 mutation from reactive gliosis.
Figure: Identification of single tumor cells in white matter distant from tumor center with antibody clone H09.
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